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Therefore, nutritional reset of m -Dys with NAD + or its natural dietary precursors could be effective in improving myocardial bioenergetics and function

11 Although low concentrations of PPA may be beneficial, humans with impairments in PPA metabolism (that is, propionic or methymalonic acidemia, holocarboxylase, biotinidase or B12 deficiency, valproate or ethanol exposure) exhibit neurodevelopmental conditions with behavioral and biochemical similarities to ASD