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'Our findings indicate that nicotine-free vape fluid exposure causes similar pro-oxidant and pro-inflammatory effects on human microvascular endothelial cells, and that ARF6 is a key regulator in vape-induced damage to blood vessels.' The ingredients in Sensa have not been made public, but Reynolds said it would list them on its website soon

their protective role may integrate not only IL-17A-mediated effects but also direct cellular interactions, antigen recognition, or secretion of other mediators

Tobacco-specific nitrosamines (TSNAs) such as N-nitrosonornicotine (NNN) and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) have been previously characterized in the vapors of e-cigarettes [35]