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PMID 8708844

Because no specific clinical or laboratory features of HRS have been identified, diagnosis depends on (1) the presence of severe liver disease, (2) a rise in creatinine to greater than 1.5 mg/dL (25.6 mol/L), (3) no evidence of other renal disease by urinalysis and clinical history, and (4) lack of improvement in renal function with treatments that increase intravascular volume (such as stopping diuretics, or administration of fluids and/or albumin)

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After 5 days without adverse effects, researchers typically increase to 0.5mg daily, then 0.75mg if needed, with 1.0mg daily as the absolute ceiling