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Since Dihexa (HGF pathway) and Semax (BDNF pathway) target independent neurotrophic systems, researchers hypothesize that combining them could produce additive or synergistic effects on synaptic density and cognitive performance

A cluster of signalling proteins included members of the granin family (VGF, CHGA and CHGB), as well as the functionally related neuropeptides TAC1, SST and CCK

193 Myo-inositol is another nutrient that has demonstrated positive effects alone and has been studied in combination with other nutrients