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Probiotics play a crucial role in modulating prostaglandin E2 (PGE2), an anti-inflammatory prostanoid that inhibits the secretion of pro-inflammatory cytokines, such as IL-1 and TNF-, by macrophages (174)

Two specific enzyme classes do most of the damage: Aminopeptidases chew peptides from the N-terminus (the front amino group end) Carboxypeptidases chew peptides from the C-terminus (the back carboxyl group end) Both are abundant in blood, in tissue, and in the GI tract

All statistical analyses were performed by using SPSS 21.0 (SPSS Inc., Chicago, IL, USA) statistical package

n = 4 animals analyzed in 2 independent experiments