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Supplementation may be indicated for individuals with dietary restrictions, certain health conditions, or increased nutritional requirements

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New England Journal of Medicine , 367(21), 19691972

Of the 50 markers investigated, 4, 11 and 25 serum and plasma analytes were significantly different from controls in mild, moderate and severe groups, respectively after false discovery rate (FDR) correction and included several well-defined pro-inflammatory cytokines, including interferon- (IFN), interleukin-6 (IL-6), interleukin-1 (IL-1), interleukin-1RA (IL-1RA), interleukin-8 (IL-8) and 10 kDa interferon gamma-induced protein (IP-10)