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When the level of ROS is too high, it induces severe oxidative stress in cells, leading to DNA, protein or lipid damage in cells, and causing cell apoptosis or necrosis

In this, calvariectomy and/or laparotomy (used to assess intracranial (superior sagittal sinus), portal, inferior caval vein and aortal pressure, and brain swelling and organs lesions and vessels presentation) since used in the therapy to counteract increased intracranial pressure and abdominal compartment syndrome [56,57], did not further contribute to the worst circumstances created by the occlusion of the superior sagittal sinus

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