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To evaluate the physiological relevance of these new spines and to determine the neurotransmitter signature of resident synapses, HGF treatment-induced spines labeled with mRFP--actin were immunostained for the universal presynaptic marker Synapsin that is located in the presynaptic active zones (Ferreira and Rapoport 2002) and the excitatory presynaptic marker VGLUT1 that is found at glutamatergic presynaptic synapses (Balschun, Moechars et al.)

We repeated these experiments in a separate cohort of tau transgenic mice

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Experiments revealed that mice lacking SIgA exhibited impaired airway mucosal immune defense, leading to abnormal bacterial colonization in the airways and subsequent progressive emphysema