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Important contraindications include personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), history of pancreatitis, severe gastrointestinal disease including gastroparesis, and pregnancy or planned pregnancy (these medications should be discontinued at least 2 months before a planned pregnancy)

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For reference, it does not provide natural protection against UV exposure

Patients who complete their full peptide cycles and attend scheduled bloodwork reviews report significantly better results than those who miss appointments or modify protocols on their own