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Apremilast, with its favorable safety profile, is a preferred option for patients with preexisting liver disease or those who experience hepatotoxicity from other systemic agents (Rajagopalan et al

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Because serum AGE levels are increased in CKD patients and are associated with decreased glomerular filtration rates ( Lysophosphatidic acid (LPA) Extracellular LPA is mainly formed by the removal of the choline moiety from plasma lysophosphatidylcholine by the phospholipase autotaxin, which can be released from adipocytes or secreted by activated platelets (111)