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Nishida Y, Montoya RH, Ostermann LB, Zhang W, Meric-Bernstam F, Kunos CA, Andreeff M

Taken together, these results suggest that the regulatory effect of USP2 on the TGF signaling pathway is heterogeneous in different tissue cells

The documented mechanisms are: VEGF stimulation in dermal fibroblasts that supports the microvascular network feeding the follicle, collagen and glycosaminoglycan synthesis at the follicular basement membrane, anti-inflammatory signaling that calms the chronic micro-inflammation associated with androgenetic alopecia, and direct follicular signaling that extends the anagen growth phase

"Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study"