melanotic macules gums Oral Macule: a small dark spot in the mouth Figure 22–5 from Pigmentations of

Considering the antioxidant effects of regular physical activity (PGC-1, PPAR) and creatine (maintaining mitochondrial integrity, acting as a cellular energy buffer, reducing extracellular H 2 O 2 levels, cell membrane stabilization and improvement of cellular energy capacity), it seems that the combined effect of physical activity and creatine consumption can reduce oxidative stress, but further research is needed to conclude more accurately about the intensity of long-term resistance and endurance training with creatine supplementation and the short-term effects of creatine consumption and physical activity on oxidative stress

G., Krediet, R

While four studies showed large effect sizes and UPDRS scores indicating improvement in PD symptoms, only three of these were statistically significant

So far, no manufacturer has completed the necessary testing for approval