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Combination of siltuximab with chemotherapies achieved an impressive ORR of 90.9% in patients with untreated multiple myeloma [353]

The evidence to back these claims is weak, the correlations are low, and many studies have not been honest in how they evaluate peoples lifestyles

We note this is consistent with our proposals to remove this LTCH from the calculation of the FY 2024 MS-LTC-DRG relative weights, the area wage level adjustment budget neutrality factor, and the fixed-loss amount for LTCH PPS standard Federal payment rate cases (discussed in section VII.B.3

18 Overall, ALC was generally well tolerated, with predominantly mild GI and CNS events, and no evidence of excess serious AEs compared with controls