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Endocannabinoids derived from omega-3 PUFAs serve as precursors to more potent bioactive compounds that operate via both cannabinoid-dependent and independent pathways, exerting anti-inflammatory, anti-proliferative, and mood-regulating effects (59, 79)

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function

3.1.3 Mechanism of antioxidant system dysfunction-mediated ferroptosis involved in ischemic stroke In addition to excessive lipid peroxidation and iron accumulation, ferroptosis-inhibiting pathways are also suppressed in IS (Figure 2B