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The drawbacks include longer application times, and some formulas may dissolve with water or sweat, which can result in an uneven appearance

Figure 1: Top 10 medicines associated with gynaecomastia in the CARM database (number of reports) Management If medicine-induced gynaecomastia is suspected, the medicine should be withdrawn or discontinued if possible 2,4

This gives Matrixyl an inherent advantage in simple cream and serum formulations

Note also that the reference ranges for serum creatinine (approximately 0.73-1.37 mg/dL = ratio 1.88), cystatin C (0.55-1.15 mg/L = ratio 2.09) and GFR (67-135 mL/min/1.73 m 2 : ratio 2.01) all have about the same relative ranges [8,9]