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4.4 Biological heterogeneity and value assessment Even if manufacturing and safety hurdles are overcome, the biological heterogeneity of the tumor microenvironment remains a central challenge for the clinical and economic value of TME-oriented nanoplatforms [67, 115]

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doi: 10.1073/pnas.93.15.7923

In addition, studies have also revealed significantly increased plasma amounts of 3-NT (3 neurotrophic factor) in patients with bipolar disorder