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Under PCAC review since October 2024

We hypothesize that SAC inhibits the E3 ubiquitin ligase activity of KEAP1 through interaction, thereby blocking the ubiquitination-mediated degradation of NRF2, stabilizing the NRF2 protein, and activating the transcription of various protective genes, including antioxidant enzymes

In this case, stopping the supplement might not result in a noticeable change because your levels were never significantly raised

In addition, tar builds up in the lungs from cigarette smoke particles and processes, producing an aqueous solution that goes through redox cycling to produce different reactive species, causing damage subsequently (61)