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Trial candidates are generally adults with type 2 diabetes and a BMI over 30 who have not achieved adequate glucose or weight control with standard therapies like metformin or a single GLP-1 agonist

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found decreased GPX4 levels in LPS-treated synoviocytes, while Icariin could inhibit synoviocyte ferroptosis and enhance cell survival in lipopolysaccharide-induced synoviocytes via the Xc /GPX4 axis (Luo and Zhang, 2021)

The regulatory and legal status of BPC-157 is that of an unapproved research compound in the United States and in most global jurisdictions, with no marketing authorization from any major regulatory agency for human therapeutic use