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It activates the SIRT1/peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) pathway to promote mitochondrial biogenesis, regulate mitochondrial homeostasis, and inhibit the high mobility group protein (HMGB)1/TLR4/p38/extracellular regulated protein kinases (ERK)1/2 pathway to reduce inflammatory responses in CIA mice (259)

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type

However, due to the crystallinity nature, high lipophilicity, and low water solubility of kojic dipalmitate, its incorporations within the topical formulations would be more challenging (Zilles et al., 2023)