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However, test-tube and animal studies show that guarana extract may boost metabolism and limit fat cell production by suppressing certain genes ( Side effects: Because guarana is high in caffeine, it may cause insomnia, headaches, nervousness and increased heart rate and anxiety, especially when taken in high doses ( Summary Guarana which is especially high in caffeine may boost metabolism, but more research is needed to determine whether it suppresses appetite or promotes weight loss

ROS accumulation in GCs disrupts mitochondrial apoptosis and reduces the expression of several transcription factors, such as GDF9 and BMP15 , which are crucial for oocyte competence

Over time, environmental damage, pollution, sun exposure, and stress can deplete glutathione levelsleading to dullness, hyperpigmentation, and premature aging

J Bioenerg Biomembr (2001) 33(6):493501