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Staphylococcus aureus mastitis isolates produce EVs containing -haemolysin, which, upon stimulation of bovine mammary epithelial cells in vitro, induce TNF- upregulation, demonstrating that pathogen-derived EVs can directly modulate mammary epithelial immune responses independent of systemic gut-derived signals

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At dose of 40 mg/kg/d for 12 weeks alogliptin caused significant decrease in TNF-, improved insulin resistance and -cell functioning in high-fat diet LDLr(-/-) male mice