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doi: 10.1055/s-0042-110491 30 WertenbruchTWillenbergHSSagertCNguyenTBBahloMFeldkampJet al

The suppression of the type I IFN response by ROS is due to oxidation of cysteine 147 of murine stimulator of IFN, an ER membrane protein that mediates the IFN response after cytoplasmic DNA sensing 59,133,134

While evidence indicates that elevated levels of soluble UA, independent of MSU crystals, directly influence the development and progression of neurological disorders, soluble UA showed robust antioxidative and anti-inflammatory effects [9]

One particular study suggested that the mechanism in which glutathione switches from eumelanin to pheomelanin production contributed to an individuals risk of acquiring skin cancers brought about by sun exposure