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In the United States, they are typically sold as research chemicals

CL Answer Risks of Too Many Vitamins & Supplements Taking too many vitamin supplements -- or taking too much of a particular supplement -- can have short and long-term adverse effects

Legal Status United States: Not FDA-approved for human use

Rhonda Patrick, a biomedical scientist and founder of FoundMyFitness, emphasizes: "NAD+ levels can go up when we exercise or fast, but NAD+ precursors like NR and NMN boost them further, supporting energy production and cellular repair."[17] She notes that combining lifestyle with supplementation yields optimal results