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Examples of possible wounds to apply NPWT (1): Diabetic foot ulcers Bed sores Skin graft fixation Burns Crush injuries Sternal/abdominal wound dehiscence Fasciotomy wounds Animal bites Frostbite Barriers to Healing Age Increased risk of tearing and shearing due to thinning of the epidermis and a decrease in elastin The phases of healing are prolonged Increased risk of dehiscence as the dermis has slower contractility Skin is more susceptible to bacterial growth and infections as pH becomes more neutral with age Co-morbidities Cardiopulmonary Disease Oxygen-transport pathways are affected O2 is necessary for wound healing Diabetes Mellitus High glycemic levels predispose patients to infection Microvasculature and neuropathic components of DM increase the risk of impaired healing Poor glycemic control can increase the risk of ulceration and delayed healing Immune-suppressing conditions (Cancer, HIV, immunosuppressive therapy, immunosuppression syndrome) Inflammatory phase (immunology) is impaired Increased risk for infection Impaired Perfusion and Oxygenation Peripheral Vascular Impairment Proper perfusion is required to support the growth of new tissue and its immunological responses

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