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This process involves carefully introducing a sterile solvent, most commonly Bacteriostatic Water, into the vial

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Finally, other mechanisms, such as cell therapy and genetic approaches, also have enormous therapeutic potential

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In line with the effect of LD on the collagen fibers, this group, later on, discovered that the MMP-2 protein expression was significantly reduced in rats treated with LD with an increased tissue inhibitor of metalloproteinase-2 (TIMP-2) expression, suggesting the influence of LD on the ECM (Wang et al., 2016)

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However, the long-term safety data are limited

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