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Materials and methods Analysis of the spontaneous reporting system database For the FAERS data, adverse event reports from the first quarter of 2004 to the last quarter of 2019 were obtained from the FDA website ( Duplicate reports were eliminated as previously reported ( As for the JADER data, adverse event reports from the first quarter of 2004 to the first quarter of 2021 were obtained from the Pharmaceuticals and Medical Devices Agency website ( A total of 693,295 reports were analyzed in this study