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Eur J Clin Pharmacol 64(4):381385 Acknowledgements We would like to thank the PF-2400013 clinical team for providing the internal validation data sets for smoker and nonsmokers from the Phase 1 study for PF-2400013

When tobacco is used in connection with alcohol, caffeine or illegal drugs, the high is amplified, leading to increased damage of the reward pathway where the dopamine neurons are situated

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