Over time, the constant excretion of cortisol begins to fatigue the adrenal glands, and because the adrenals produce reserve stores of sex hormones, such as estrogen, progesterone, and testosterone, it may cause the body to steal the materials needed to make these sex hormones and convert them into more cortisol
Aggregated peptides pose a particular concern
Increases in the expression of various molecules that have been noted in reactive astrocytes across multiple contexts include GFAP, vimentin, nestin (probably labelling proliferating astrocytes), synemin plectin, -crystallin B chain, monoaminoxodase-B (MAO-B), heat shock factor binding protein 1, complement C3, lipocalin 2, C-X-C motif chemokine ligand 10, SerpinA3N, LCN2 and others, 20,95,96,97,98,99,100,101,102,103 but it important to note that no single molecular marker (including GFAP) is an absolute, required and sufficient, indicator of astrocyte reactivity, and no molecular markers have yet been identified that reliably distinguish amongst different reactive astrocyte phenotypes
This targeted method could maximize benefits while reducing unnecessary supplements
