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McCoy and colleagues reported that 5-day treatment of dissociated rat hippocampal neurons with Dihexa increased dendritic spine density approximately three-fold compared to vehicle control (~41 spines per 50 m of dendrite versus ~15 spines), with the increase reflecting both new spine formation and increased spine-head width consistent with synaptic maturation [2]

Dib J, Tretzel L, Piper T, Logajda A, Khne D, Schnzer W, Thevis M

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