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RNA-sequencing analysis The culture medium containing 20% EMFF or 20% COFF was added to KGN

Concurrently, the expression levels of heme oxygenase-1 (HO-1) and kelch-like ECH-associated protein 1 (KEAP1) are also significantly elevated [17]

Additionally, the intracellular GSH concentration of the strain carrying the mutant GSH I was 1.3-fold higher than that of the control [8]

In some embodiments, the formulation or composition provides a 0.25:1 ratio, or a 0.5:1 ratio, or a 1:1 ratio, or a 1:2 ratio, or a 1:3, or a 1:4 ratio, or a 1:5 ratio, or a 1:7 ratio, or a 1:10 ratio, or a 1: 15 ratio, or a 1:20 ratio of immediate release and extended release formulations or compositions of a first otic agent and second therapeutic agent, respectively