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Compounds such as erastin and sulfasalazine, which inhibit system Xc , reduce cysteine availability, compromise GSH synthesis, and decrease GPX4 activity, thereby triggering ferroptosis (258)

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To explore the regulatory effects and mechanism of PDA@Pt on joint inflammation, we performed immunofluorescence assays on the ankle joints, assessing changes in inflammatory markers (IL-6, IL-1, TNF-) and the inflammatory signaling pathway (NF-B(P65))