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Who Should Avoid It Pregnancy and breastfeeding Concurrent MAOI use Stop Right Away If You Notice Serotonin syndrome signs Severe persistent headaches Cardiac symptoms Seizure activity Severe mood changes or suicidal ideation Milder Signs to Watch For How Long Should a PE-22-28 Cycle Last

(In other words: Some work, some don't

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PMID: 11354389 DOI: 10.1016/s0149-2918(01)80059-x Zapukhliak O et al (2021): Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors