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Another study reported BD patients (75 euthymic, 14 manic/hypomanic, 45 depressive) had higher levels of all cytokines, including slL-2R, C-reactive protein (CRP) and sTNFR1 than the healthy controls [73], with depressed BD patients having reduced sTNFRl and slL-2R compared to those in mania and euthymia [73]

Pollard & Pomfrett claim that a dose of DSIP given during the course of the day will promote improved sleep on the next night and for several nights thereafter,4 so the dose frequency here could be an example of less frequent administration