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Some clinicians recommend keeping the dissolved tablet residue in the mouth for an additional 2 to 3 minutes after the tablet has physically dissolved, as residual semaglutide may continue absorbing through the oral mucosa during this period

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Although osteoporosis was generally observed to develop within 46 weeks, significant osteoporosis was ensured by waiting 8 weeks post ovariectomy and then confirming osteoporosis by analysis of bone mineral density prior to inducing bone fracture

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