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b) social co-benefits, including ecosystem services, cultural significance, and community reliance

consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calciumphosphateparathyroid hormone (PTH) monitoringrather than positioning vitamin D as disease-modifying therapy for unselected CKD

The phosphorylated USP33 deubiquitinated arrestins locally, rather than globally, because USP33 specifically bound to arrestins associated with D 3 R and Mdm2 (Fig

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