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Refinement can include an enrichment of animals environment, such as game or reward which can improve overall well-being 4,5 and the introduction of endpoints that allow humans to assess animal suffering

All of PubMed contains fewer than 20 papers mentioning dihexa, and a chunk of those are the liver-cell manufacturing papers described above

DRB-00104 Alpha Lipoic Acid Fact Sheet

Thus, this pilot study has laid a foundation for the successful implementation of immunogenicity and efficacy vaccination trials in larger cohorts in Asian elephant range countries and may provide a roadmap for vaccination studies of other wildlife diseases