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These toxins can similarly cause an asthma patient's airways to swell, making it more difficult to breathe

(In September 2023, PMI announced the development of a new line of IQOS refills that contain no tobacco

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Yves Saint Laurent is arguably the most successful of these (even though he admitted in a 1968 interview he smokes, but not his namesake brand, as he does "not like the flavour"), though many other brands have been marketed, from time to time, in select international markets: Givenchy, Versace, Pierre Cardin, Christian Lacroix and Cartier (a jewelry house)