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STEP UP directly compared 7.2 mg with 2.4 mg and placebo over 72 weeks: FDA prescribing information

D, L-Hcy thiolactone hydrochloride was purchased from Lancaster, England

They associated the early phase with monomers, the middle phase with soluble oligomers, and the final phase with insoluble fibrils

Although the specific molecular mechanisms of Ybp1 are not yet fully understood, it is hypothesized that Ybp1 plays a role in relaying signals from Gpx3 to Yap1