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The expression of malondialdehyde (MDA) H 2 O 2 was significantly increased in the paw tissue of CIA mice, and intervention with curarelinone, the active ingredient of bitter ginseng, significantly inhibited oxidative damage and decreased the phosphorylation levels of signal transducer and activator of transcription (STAT)1, STAT3, and ratio of Th1 and Th17 cells in lymph nodes (62)

Infection, some medications and foods with high level of convicine, vicine, divicine and isouramil such as fava beans can cause oxidative stress

Good practices include detox support, hydration, gut health, and focus on keeping down inflammation

It was discovered in the 1990s by Croatian researchers studying gastric protective factors