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Yes, hyperthyroidism can affect the skin in several ways: Hyperpigmentation (melasma): Hormonal shifts, such as increased ACTH, may lead to darker patches of skin Excess sweating and rashes: Heat rashes often appear in skin folds due to higher sweat production Pretibial myxedema: A rare condition where the skin on the shins or tops of the feet becomes red, thickened, and swollen Associated autoimmune conditions: People with Graves disease may also develop vitiligo (loss of skin pigment) or alopecia areata (patchy hair loss) Functional medicine treatment considers both the thyroid imbalance and its skin manifestations, helping reduce symptoms and improve overall wellbeing

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One accelerates skin renewal through nuclear receptors

The significance of this paper is not only to compare the three routes of administration but also to evaluate them and determine which route is the best to administrate the drug