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Description

The reported side effects are similar across genders

10.1074/jbc.C100273200 J

When it gets to the end of a strand, its not a perfect fit on the end (the mechanics of this is a little complicated) and needs a bit of scratch DNA at the end of the strand to successfully complete the DNA replication

There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses