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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007
This mechanism is not fully elucidated and it is possible that it acts via the IGF-1 receptor (not GHR) in localized concentrations
-Malabsorption (insufficient absorption of vitamin B12 in the intestine) due to insufficient production of intrinsic factor (a protein that is produced in the stomach lining and is required for the absorption of vitamin B12), diseases in the end section of the ileum (part of the small intestine), e.g.E.g
Patients walk in on their lunch break, get the injection, and are back at their desk before the end of their hour
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