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These studies report increased abundance of bacterial groups including Negativicutes , Christensenellaceae , Selenomonadales , and Ruminococcus , alongside a notable decrease in Verrucomicrobia , Akkermansia muciniphila , and Erysipelotrichaceae UCG003 showed an decrease (Liu et al., 2023)

It can interfere with JAK signal transduction and STAT signaling pathway by inhibiting the activity of one or more JAKs, and simultaneously inhibit the production of multiple cytokines to reduce inflammation and inflammation-related pain (225, 226)