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Tirzepatide vs semaglutide 1 mg in T2D SURPASS-2, HbA1c -2.01/-2.24/-2.30 pp, weight dose-responsive while HbA1c saturates: Frias NEJM 2021

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)