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Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]

Eur J Pharmacol 379:1931 Jelovac N, Sikiric P, Rucman R et al (1999b) The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam

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[DOI] [PubMed] [Google Scholar] 24.Reifen R., Berkovich Z., Mandelberg A