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Despite remarkable advances in the diagnosis and management of male infertility, almost one half of all cases still idiopathic, for which no evident etiological factor has been identified (5)

Thymosin 4 Promotes Angiogenesis, Wound Healing, and Hair Follicle Development, Mechanisms of Ageing and Development, 2004

This aging mechanism is closely related to various common diseases, including atherosclerosis, hypertension, chronic obstructive pulmonary disease, diabetes, and neurodegenerative disorders ( Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib ( Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs

[4] Gwyer D, Wragg NM, Wilson SL