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If caloric intake exceeds expenditure, the enhanced lipolysis may be offset by continued fat storage

[16] There is no advantage to the use of adenosylcobalamin or methylcobalamin forms for the treatment of vitamin B 12 deficiency

The Kraus 2014 study reported that adipocyte-specific NNMT knockdown in mice increased adipocyte energy expenditure through a mechanism interpreted as elevated methyl-donor availability for polyamine biosynthesis and for histone methylation that modulates adipocyte gene-expression programs [2]

It improves glucose metabolism in skeletal muscle, which implies a number of benefits for those with diabetes, obesity, or who are over 30 years old