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In addition, they uncovered a five- or-more-fold increase in the signaling of the KRAS oncogene, which is often mutated in smoking-related lung cancer

A report of Canadian warnings indicated that pictorial cigarette warnings improved knowledge of specific negative health effects of smoking among adolescents (e.g., increased knowledge of bladder cancer, impotence in men, mouth cancer, gum or mouth disease, reduced growth in babies during pregnancy, and strokes) (Ref

In basic speak, that means the smoke your good pal is blowing out from that Black D.O.G

But at the end of the day, its a soft tissue casea bulging disc on a 60-something-year-old with one injection