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Without supplementation, deficiency is nearly universal within 23 years People taking metformin long-term metformin use reduces B12 absorption by 1030% through calcium-dependent ileal uptake disruption [4] People taking PPIs or H2 blockers acid suppression impairs B12 release from food proteins

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Still in clinical development, early studies suggest it may deliver even greater weight loss than current drugs, but it is not yet available for general use