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Risk-reducing salpingo-oophorectomy is advised for BRCA carriers once child-bearing is complete, lowering lifetime incidence by up to 90% but inducing surgical menopause [57, 58]

To maintain enough H 2 O levels for hormone production without causing oxidative damage, GPX activity is necessary [16]

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However, it is essential to recognize that while macrophages are the target cells in all clinical manifestations of leishmaniasis, the affected organs may vary